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Article

Tau alternative splicing in familial and sporadic tauopathies

20 Jul 2012

Abstract excerpt

Six tau isoforms differing in their affinity for microtubules are produced by alternative splicing from the MAPT (microtubule-associated protein tau) gene in adult human brain. Several MAPT mutations causing the familial tauopathy, FTDP-17 (frontotemporal dementia with parkinsonism linked to chromosome 17), affect alternative splicing of exon 10, encoding a microtubule-binding motif. Advanced RNA analysis methods...

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PMID: 22817715
DOI: 10.1042/bst20120091

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