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Article

Regulation of tau isoform expression and dementia.

Biochimica et biophysica acta - 3 Jan 2005

D'Souza Ian, Schellenberg Gerard D

Abstract excerpt

In the central nervous system (CNS), aberrant changes in tau mRNA splicing and consequently in protein isoform ratios cause abnormal aggregation of tau and neurodegeneration. Pathological tau causes neuronal loss in Alzheimer's disease (AD) and a diverse group of disorders called the frontotemporal dementias (FTD), which are two of the most common forms of dementia and afflict more than 10% of the elderly...

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Source

Identifiers

PMID: 15615630
DOI: 10.1016/j.bbadis.2004.08.009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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