Article
Tau mis-splicing in the pathogenesis of neurodegenerative disorders.
BMB reports - 1 Aug 2016
Park Sun Ah, Ahn Sang Il, Gallo Jean-Marc
Abstract excerpt
Tau proteins, which stabilize the structure and regulate the dynamics of microtubules, also play important roles in axonal transport and signal transduction. Tau proteins are missorted, aggregated, and found as tau inclusions under many pathological conditions associated with neurodegenerative disorders, which are collectively known as tauopathies. In the adult human brain, tau protein can be expressed in six...
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