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Mutations in Lyar and p53 are synergistically lethal in female mice.

Birth defects research. Part A, Clinical and molecular teratology - 1 Sept 2012

Wang Guan, Fulkerson Christopher M, Malek Reem, Ghassemifar Sara, Snyder Paul W, Mendrysa Susan M

Abstract excerpt

BACKGROUND: Ly-1 antibody reactive clone (LYAR) is a nucleolar zinc finger protein that has been implicated in cell growth, self-renewal of embryonic stem cells, and medulloblastoma. To test whether LYAR is critical for cell growth and development, we generated Lyar mutant mice. METHODS: Mice carrying the mutant Lyar(gt) allele were generated from embryonic stem cells that contained a gene-trap insertion in the...

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Source

Identifiers

PMID: 22815056
DOI: 10.1002/bdra.23048

Genes

LYAR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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