Article
Rpl27a mutation in the sooty foot ataxia mouse phenocopies high p53 mouse models.
The Journal of pathology - 1 Aug 2011
Terzian Tamara, Dumble Melissa, Arbab Farinaz, Thaller Christina, Donehower Lawrence A, Lozano Guillermina, Justice Monica J, Roop Dennis R, Box Neil F
Abstract excerpt
Ribosomal stress is an important, yet poorly understood, mechanism that results in activation of the p53 tumour suppressor. We present a mutation in the ribosomal protein Rpl27a gene (sooty foot ataxia mice), isolated through a sensitized N-ethyl-N-nitrosourea (ENU) mutagenesis screen for p53 pathway defects, that shares striking phenotypic similarities with high p53 mouse models, including cerebellar ataxia,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.