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Article

Rlip depletion prevents spontaneous neoplasia in TP53 null mice

23 Mar 2018

Abstract excerpt

Significance Mice that have homozygous deletion of the p53 tumor suppressor protein universally die of malignancy, generally before 6 months of age. We show that hemizygous deficiency of RALBP1 (RLIP76 or Rlip) confers a degree of protection from spontaneous malignancy that has never previously been observed. This discovery introduces a paradigm for p53 function, in which Rlip plays a central role as an effector...

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PMID: 29572430
DOI: 10.1073/pnas.1719586115

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