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Article

p53 Activation in Genetic Disorders: Different Routes to the Same Destination.

International journal of molecular sciences - 27 Aug 2021

Tsai Yu-Young, Su Chun-Hao, Tarn Woan-Yuh

Abstract excerpt

The tumor suppressor p53 is critical for preventing neoplastic transformation and tumor progression. Inappropriate activation of p53, however, has been observed in a number of human inherited disorders that most often affect development of the brain, craniofacial region, limb skeleton, and hematopoietic system. Genes related to these developmental disorders are essentially involved in transcriptional...

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Share to Cell Transformation, Neoplastic
Share to Genetic Diseases, Inborn
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34502215
DOI: 10.3390/ijms22179307
PMCID: PMC8430931

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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