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Article

Pharmacogenomics of anesthetic drugs in transgenic LQT1 and LQT2 rabbits reveal genotype-specific differential effects on cardiac repolarization.

American journal of physiology. Heart and circulatory physiology - 1 Dec 2008

Odening Katja E, Hyder Omar, Chaves Leonard, Schofield Lorraine, Brunner Michael, Kirk Malcolm, Zehender Manfred, Peng Xuwen, Koren Gideon

Abstract excerpt

Anesthetic agents prolong cardiac repolarization by blocking ion currents. However, the clinical relevance of this blockade in subjects with reduced repolarization reserve is unknown. We have generated transgenic long QT syndromes type 1 (LQT1) and type 2 (LQT2) rabbits that lack slow delayed rectifier K+ currents (IKs) or rapidly activating K+ currents (IKr) and used them as a model system to detect the...

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Source

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Identifiers

PMID: 18835916
DOI: 10.1152/ajpheart.00680.2008
PMCID: PMC2614544

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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