Article
An unexpected role for TASK-3 potassium channels in network oscillations with implications for sleep mechanisms and anesthetic action.
Proceedings of the National Academy of Sciences of the United States of America - 13 Oct 2009
Pang Daniel S J, Robledo Christian J, Carr David R, Gent Thomas C, Vyssotski Alexei L, Caley Alex, Zecharia Anna Y, Wisden William, Brickley Stephen G, Franks Nicholas P
Abstract excerpt
TASK channels are acid-sensitive and anesthetic-activated members of the family of two-pore-domain potassium channels. We have made the surprising discovery that the genetic ablation of TASK-3 channels eliminates a specific type of theta oscillation in the cortical electroencephalogram (EEG) resembling type II theta (4-9 Hz), which is thought to be important in processing sensory stimuli before initiating motor...
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