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Article

Acute atrial arrhythmogenicity and altered Ca(2+) homeostasis in murine RyR2-P2328S hearts.

Cardiovascular research - 1 Mar 2011

Zhang Yanmin, Fraser James A, Jeevaratnam Kamalan, Hao Xiaojin, Hothi Sandeep S, Grace Andrew A, Lei Ming, Huang Christopher L-H

Abstract excerpt

AIMS: The experiments explored for atrial arrhythmogenesis and its possible physiological background in recently developed hetero-(RyR2(+/S)) and homozygotic (RyR2(S/S)) RyR2-P2328S murine models for catecholaminergic polymorphic ventricular tachycardia (VT) for the first time. They complement previous clinical and experimental reports describing increased ventricular arrhythmic tendencies associated with...

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Identifiers

PMID: 20621925
DOI: 10.1093/cvr/cvq229
PMCID: PMC3039245

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