Article
Bidirectional ventricular tachycardia and fibrillation elicited in a knock-in mouse model carrier of a mutation in the cardiac ryanodine receptor.
Circulation research - 27 May 2005
Cerrone Marina, Colombi Barbara, Santoro Massimo, di Barletta Marina Raffaele, Scelsi Mario, Villani Laura, Napolitano Carlo, Priori Silvia G
Abstract excerpt
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited disease characterized by adrenergically mediated polymorphic ventricular tachycardia leading to syncope and sudden cardiac death. The autosomal dominant form of CPVT is caused by mutations in the RyR2 gene encoding the cardiac isoform of the ryanodine receptor. In vitro functional characterization of mutant RyR2 channels showed altered...
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