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Genome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma

25 Sept 2018

Abstract excerpt

Diffuse large B-cell lymphoma (DLBCL) is an aggressive cancer originating from mature B-cells. Prognosis is strongly associated with molecular subgroup, although the driver mutations that distinguish the two main subgroups remain poorly defined. Through an integrative analysis of whole genomes, exomes, and transcriptomes, we have uncovered genes and non-coding loci that are commonly mutated in DLBCL. Our analysis...

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PMID: 30275490
DOI: 10.1038/s41467-018-06354-3

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