Article
Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing.
Proceedings of the National Academy of Sciences of the United States of America - 6 Mar 2012
Lohr Jens G, Stojanov Petar, Lawrence Michael S, Auclair Daniel, Chapuy Bjoern, Sougnez Carrie, Cruz-Gordillo Peter, Knoechel Birgit, Asmann Yan W, Slager Susan L, Novak Anne J, Dogan Ahmet, Ansell Stephen M, Link Brian K, Zou Lihua, Gould Joshua, Saksena Gordon, Stransky Nicolas, Rangel-Escareño Claudia, Fernandez-Lopez Juan Carlos, Hidalgo-Miranda Alfredo, Melendez-Zajgla Jorge, Hernández-Lemus Enrique, Schwarz-Cruz y Celis Angela, Imaz-Rosshandler Ivan, Ojesina Akinyemi I, Jung Joonil, Pedamallu Chandra S, Lander Eric S, Habermann Thomas M, Cerhan James R, Shipp Margaret A, Getz Gad, Golub Todd R
Abstract excerpt
To gain insight into the genomic basis of diffuse large B-cell lymphoma (DLBCL), we performed massively parallel whole-exome sequencing of 55 primary tumor samples from patients with DLBCL and matched normal tissue. We identified recurrent mutations in genes that are well known to be functionally...
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