Article
LRRK2 A419V is not associated with Parkinson's disease in different Chinese populations.
PloS one - 1 Jan 2012
Wu Yih Ru, Tan Louis C, Fu Xiaoli, Chen Chiung Mei, Au Wing Lok, Chen Ling, Chen Yi Chun, Prakash Kumar M, Zheng Yifan, Lee-Chen Guey-Jen, Zhao Yi, Zeng Jin-Sheng, Tan Eng King, Pei Zhong
Abstract excerpt
It has been suggested that a common LRRK2 polymorphic variant (A419V (rs34594498 C >T)) may be a risk factor among Asians (especially in Taiwan). In this study, we examined this variant in a larger and independent Taiwan cohort. We found the frequency of the variant (A419V) to be very rare in our Taiwan PD and controls (?0.6%). Further studies were conducted in two other Chinese populations (Singapore and China),...
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