Article
Genetic analysis of LRRK2 A419V variant in ethnic Chinese.
Neurobiology of aging - 1 Aug 2012
Li Nan-Nan, Tan Eng-King, Chang Xue-Li, Mao Xue-Ye, Zhang Jin-Hong, Zhao Dong-Mei, Liao Qiao, Peng Rong
Abstract excerpt
Mutations in the leucine-rich repeat kinase 2 gene (LRRK2) are the most common causes of autosomal dominant and sporadic forms of Parkinson's disease (PD). The A419V variant has been suggested to be a potential risk variant but its role among Chinese is unclear. We genotyped LRRK2 A419V variant to investigate the association with risk of PD. A total of 1314 subjects comprising 729 patients with PD and 585...
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