Article
Lack of G2019S LRRK2 mutation in a cohort of Taiwanese with sporadic Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society - 1 Jun 2006
Fung Hon-Chung, Chen Chiung-Mei, Hardy John, Hernandez Dena, Singleton Andrew, Wu Yih-Ru
Abstract excerpt
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been shown to cause autosomal dominant and sporadic Parkinson's disease (PD). We report here the frequency of a common heterozygous mutation, 2877510G>A, which produces a glycine-to-serine amino acid substitution at codon 2019 in idi...
Topics
- Adult
- Aged
- Aged, 80 and over
- Amino Acid Substitution
- Female
- Founder Effect
- Gene Frequency
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Male
- Middle Aged
- Mutation
- Parkinson Disease
- Protein Serine-Threonine Kinases
- Taiwan