Article
Lack of G2019S LRRK2 mutation in a cohort of Taiwanese with sporadic Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society - 1 Jun 2006
Fung Hon-Chung, Chen Chiung-Mei, Hardy John, Hernandez Dena, Singleton Andrew, Wu Yih-Ru
Abstract excerpt
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been shown to cause autosomal dominant and sporadic Parkinson's disease (PD). We report here the frequency of a common heterozygous mutation, 2877510G>A, which produces a glycine-to-serine amino acid substitution at codon 2019 in idiopathic Taiwanese PD. The extreme rarity of the G2019S mutation in our population suggests the occurrence of this...
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