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Expression and Function of CD300 in NK Cells

23 Jul 2010

Abstract excerpt

The killing activity of NK cells is regulated by signals derived from inhibitory and activating NK cell receptors, including the CD300 family of proteins. CD300a was reported to be expressed on all NK cells and to deliver an inhibitory signal upon binding to a yet unknown ligand/s. The CD300a protein contains four ITIMs and is highly homologous to CD300c. Little is known about the function and distribution of...

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PMID: 20656921
DOI: 10.4049/jimmunol.0903347

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