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Human NKG2D-ligands: cell biology strategies to ensure immune recognition

1 Jan 2012

Abstract excerpt

Immune recognition mediated by the activating receptor NKG2D plays an important role for the elimination of stressed cells, including tumors and virus-infected cells. On the other hand, the ligands for NKG2D can also be shed into the sera of cancer patients where they weaken the immune response by downmodulating the receptor on effector cells, mainly NK and T cells. Although both families of NKG2D-ligands, major...

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PMID: 23056001
DOI: 10.3389/fimmu.2012.00299

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