Article
Distinct Signatures in the Receptor Repertoire Discriminate CD56bright and CD56dim Natural Killer Cells.
Frontiers in immunology - 1 Jan 2020
Schwane Vera, Huynh-Tran Van Hung, Vollmers Sarah, Yakup Vivien Maria, Sauter Jürgen, Schmidt Alexander H, Peine Sven, Altfeld Marcus, Richert Laura, Körner Christian
Abstract excerpt
NK cells are phenotypically and functionally diverse lymphocytes due to variegated expression of a large array of receptors. NK-cell activity is tightly regulated through integration of receptor-derived inhibitory and activating signals. Thus, the receptor profile of each NK cell ultimately determines its ability to sense aberrant cells and subsequently mediate anti-viral or anti-tumor responses. However, an...
Topics
- CD56 Antigen
- Humans
- Killer Cells, Natural
- Phenotype