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Article

Crystal structure of extracellular domain of human lectin-like transcript 1 (LLT1), the ligand for natural killer receptor-P1A.

European journal of immunology - 1 Jun 2015

Kita Shunsuke, Matsubara Haruki, Kasai Yoshiyuki, Tamaoki Takaharu, Okabe Yuki, Fukuhara Hideo, Kamishikiryo Jun, Krayukhina Elena, Uchiyama Susumu, Ose Toyoyuki, Kuroki Kimiko, Maenaka Katsumi

Abstract excerpt

Emerging evidence has revealed the pivotal roles of C-type lectin-like receptors (CTLRs) in the regulation of a wide range of immune responses. Human natural killer cell receptor-P1A (NKRP1A) is one of the CTLRs and recognizes another CTLR, lectin-like transcript 1 (LLT1) on target cells to control NK, NKT and Th17 cells. The structural basis for the NKRP1A-LLT1 interaction was limitedly understood. Here, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 25826155
DOI: 10.1002/eji.201545509

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