Article
Genetics, genomics, and evolutionary biology of NKG2D ligands.
Immunological reviews - 1 Sept 2015
Carapito Raphael, Bahram Seiamak
Abstract excerpt
Human and mouse NKG2D ligands (NKG2DLs) are absent or only poorly expressed by most normal cells but are upregulated by cell stress, hence, alerting the immune system in case of malignancy or infection. Although these ligands are numerous and highly variable (at genetic, genomic, structural, and biochemical levels), they all belong to the major histocompatibility complex class I gene superfamily and bind to a...
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