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Article

Transcriptional Activation of the MUC2 Gene by p53

1 Dec 2002

Abstract excerpt

MUC2 is one of the major components of mucins that provide a protective barrier between epithelial surfaces and the gut lumen. We investigated possible alterations of MUC2 gene expression by p53 and p21(Sdi1/Waf1/Cip1) in a human colon cancer cell line, DLD-1, establishing subclones in which a tetracycline-regulatable promoter controls exogenous p53 and p21 expression. MUC2 mRNA more significantly increased in...

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PMID: 12374798
DOI: 10.1074/jbc.m207986200

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