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Article

Identification of the <i>Osteopontin</i> gene as a direct target of TP53

26 Dec 2001

Abstract excerpt

The TP53 tumor suppressor gene regulates a number of genes that are involved in cell-cycle inhibition, apoptosis, and maintaining genetic stability. Recently, two genes that have a role in immunosurveillance were identified as downstream targets of TP53. These genes, TAP1 and fractalkine, may contribute to suppress tumor growth through host immunosurveillance. It has been reported that the mouse secreted...

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PMID: 11807984
DOI: 10.1002/gcc.10020

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Identification of the <i>Osteopontin</i> gene as a direct target of TP53PMID 11807984Read ↗

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An osteopontin/CD44 immune checkpoint controls CD8+ T cell activation and tumor immune evasionSemantic proximity Read ↗

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