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Article

Regulation of MCP-1 chemokine transcription by p53

20 Apr 2010

Abstract excerpt

BACKGROUND: Our previous studies showed that the expression of the monocyte-chemoattractant protein (MCP)-1, a chemokine, which triggers the infiltration and activation of cells of the monocyte-macrophage lineage, is abrogated in human papillomavirus (HPV)-positive premalignant and malignant cells. In silico analysis of the MCP-1 upstream region proposed a putative p53 binding side about 2.5 kb upstream of the...

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PMID: 20406462
DOI: 10.1186/1476-4598-9-82

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