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Article

Transposon-Sequencing Analysis Unveils Novel Genes Involved in the Generation of Persister Cells in Uropathogenic Escherichia coli.

Antimicrobial agents and chemotherapy - 1 Nov 2016

Molina-Quiroz Roberto C, Lazinski David W, Camilli Andrew, Levy Stuart B

Abstract excerpt

Persister cells are highly tolerant to different antibiotics and are associated with relapsing infections. In order to understand this phenomenon further, we exposed a transposon library to a lethal concentration of ampicillin, and mutants that survived were identified by transposon sequencing (Tn-Seq). We determined that mutations related to carbon metabolism, cell envelope (cell wall generation and membrane...

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Identifiers

PMID: 27550350
DOI: 10.1128/AAC.01617-16
PMCID: PMC5075105

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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