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Article

Carbonylhydrazide-based molecular tongs inhibit wild-type and mutated HIV-1 protease dimerization.

Journal of medicinal chemistry - 9 Aug 2012

Dufau Laure, Marques Ressurreição Ana Sofia, Fanelli Roberto, Kihal Nadjib, Vidu Anamaria, Milcent Thierry, Soulier Jean-Louis, Rodrigo Jordi, Desvergne Audrey, Leblanc Karine, Bernadat Guillaume, Crousse Benoit, Reboud-Ravaux Michèle, Ongeri Sandrine

Abstract excerpt

We have designed and synthesized new molecular tongs based on a rigid naphthalene scaffold and evaluated their antidimer activity on HIV-1 protease (PR). We inserted carbonylhydrazide and oligohydrazide (azatide) fragments into their peptidomimetic arms to reduce hydrophobicity and increase metab...

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PMID: 22800535
DOI: 10.1021/jm300181j

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22800535-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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