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Article

Molecular tongs containing amino acid mimetic fragments: new inhibitors of wild-type and mutated HIV-1 protease dimerization.

Journal of medicinal chemistry - 27 Jul 2006

Bannwarth Ludovic, Kessler Albane, Pèthe Stéphanie, Collinet Bruno, Merabet Naïma, Boggetto Nicole, Sicsic Sames, Reboud-Ravaux Michèle, Ongeri Sandrine

Abstract excerpt

We have designed, synthesized, and evaluated the inhibitory activity and metabolic stability of new peptidomimetic molecular tongs based on a naphthalene scaffold for inhibiting HIV-1 protease dimerization. Peptidomimetic motifs were inserted into one peptidic strand to make it resistant to proteolysis. The peptidic character of the molecular tongs can be decreased without changing the way they inhibit...

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Identifiers

PMID: 16854071
DOI: 10.1021/jm060576k

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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