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Article

Molecular tongs containing amino acid mimetic fragments: new inhibitors of wild-type and mutated HIV-1 protease dimerization.

Journal of medicinal chemistry - 27 Jul 2006

Bannwarth Ludovic, Kessler Albane, Pèthe Stéphanie, Collinet Bruno, Merabet Naïma, Boggetto Nicole, Sicsic Sames, Reboud-Ravaux Michèle, Ongeri Sandrine

Abstract excerpt

We have designed, synthesized, and evaluated the inhibitory activity and metabolic stability of new peptidomimetic molecular tongs based on a naphthalene scaffold for inhibiting HIV-1 protease dimerization. Peptidomimetic motifs were inserted into one peptidic strand to make it resistant to prote...

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Identifiers

PMID: 16854071
DOI: 10.1021/jm060576k

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16854071-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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