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Article

Enhancing Protein Backbone Binding—A Fruitful Concept for Combating Drug‐Resistant HIV

31 Jan 2012

Abstract excerpt

The evolution of drug resistance is one of the most fundamental problems in medicine. In HIV/AIDS, the rapid emergence of drug-resistant HIV-1 variants is a major obstacle to current treatments. HIV-1 protease inhibitors are essential components of present antiretroviral therapies. However, with these protease inhibitors, resistance occurs through viral mutations that alter inhibitor binding, resulting in a loss...

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PMID: 22290878
DOI: 10.1002/anie.201102762

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