Article

Allosteric capsid inhibitors and their escape mutants drive HIV-1 sensing

2026-08-26

Abstract excerpt

Small-molecule capsid inhibitors suppress HIV-1 infectivity by binding to capsid at the same site as FG motif-bearing host cofactors Sec24C, NUP153, CPSF6 and disordered nucleoporins residing in the nuclear pore complex central channel. We have used rational design to develop inhibitors called "allosteres" that target this pocket and inhibit HIV-1 infectivity. X-ray crystal structures of capsid/inhibitor complexes...

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Literature Corpus work: e5e08975-50fa-54cd-b732-6fe0b08bbfaa
DOI: 10.64898/2026.08.21.746246

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