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Article

Development of low molecular weight HIV-1 protease dimerization inhibitors.

Journal of medicinal chemistry - 24 Mar 2005

Hwang You Seok, Chmielewski Jean

Abstract excerpt

The role of HIV protease in viral replication has made it a significant target for inhibition. The focus of our studies is to target the dimerization interface of HIV-1 protease because disruption of the dimer will inhibit enzymatic activity. The initial strategy began with cross-linked peptides derived from the interface of HIV protease. Herein we describe the design of a focused library of agents based on a...

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Identifiers

PMID: 15771466
DOI: 10.1021/jm049581j

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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