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Article

Toward the first nonpeptidic molecular tong inhibitor of wild-type and mutated HIV-1 protease dimerization.

ChemMedChem - 8 Nov 2010

Vidu Anamaria, Dufau Laure, Bannwarth Ludovic, Soulier Jean-Louis, Sicsic Sames, Piarulli Umberto, Reboud-Ravaux Michèle, Ongeri Sandrine

Abstract excerpt

Herein we describe the synthesis and HIV-1 protease (PR) inhibitory activity of 16 new peptidomimetic molecular tongs with a naphthalene scaffold. Their peptidic character was progressively decreased. Two of these molecules exhibited the best dimerization inhibition activity toward HIV-1 wild-typ...

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Source

Identifiers

PMID: 20936621
DOI: 10.1002/cmdc.201000308

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20936621-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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