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Article

A quick diversity-oriented amide-forming reaction to optimize P-subsite residues of HIV protease inhibitors.

Chemistry & biology - 1 Aug 2002

Brik Ashraf, Lin Ying-Chuan, Elder John, Wong Chi-Huey

Abstract excerpt

We report a new simple method that allows rapid preparation in solution of a library of compounds for in situ high-throughput screening to identify new inhibitors of HIV-1 protease. The method is based on the amide-forming reaction of a C(2)-symmetrical diamino diol core with various carboxylic acids, followed by a direct assay of the inhibition activity without product isolation. Sixty-two compounds were made...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12204688
DOI: 10.1016/s1074-5521(02)00184-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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