Article
Association of two mutations in the CHEK2 gene with breast cancer.
International journal of cancer - 20 Aug 2005
Bogdanova Natalia, Enssen-Dubrowinskaja Natalia, Feshchenko Sergei, Lazjuk Gennady I, Rogov Yuri I, Dammann Olaf, Bremer Michael, Karstens Johann H, Sohn Christof, Dörk Thilo
Abstract excerpt
The 1100delC mutation of the cell cycle checkpoint kinase 2 (CHEK2) gene confers an increased risk for breast cancer, but the clinical impact of other CHEK2 gene variants remains unclear. We determined the frequency of two functionally relevant CHEK2 gene mutations, I157T and IVS2+1G > A, in two large series of breast cancer cases and controls from two independent populations. Our first series consisted of a...
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