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Article

CHEK2 I157T and endometrial cancer.

DNA and cell biology - 1 Jan 2009

Konstantinova Darina V, Kadiyska Tanya K, Kaneva Radka P, Tosheva Elena G, Guseva Violeta T, Dimitrov Borislav H, Dimitrov Roumen G, Doganov Nikolay I, Ivanov Stephan I, Kremensky Ivo M, Mitev Vanio I

Abstract excerpt

Endometrial cancer (EC) is the most common malignancy of the female reproductive system in the industrialized world. Similar to other common diseases, gene variations are believed to be able to alter an individual's predisposition to developing the disease. The CHEK2 gene encodes a tumor suppressor that takes part in various cell processes, including cell cycle regulation, DNA repair, and apoptosis. The...

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Identifiers

PMID: 18834326
DOI: 10.1089/dna.2008.0781

Genes

CHEK2

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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Related research

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CHEK2 I157T and endometrial cancer.PMID 18834326Read ↗

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The CHEK2 I157T variant and colorectal cancer susceptibility: a systematic review and meta-analysis.Semantic proximity Read ↗

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The effect of CHEK2 variant I157T on cancer susceptibility: evidence from a meta-analysis.Semantic proximity Read ↗

CHEK2 I157T and colorectal cancer in Bulgaria.Semantic proximity Read ↗

Common variants at the CHEK2 gene locus and risk of epithelial ovarian cancer.Semantic proximity Read ↗

Germline CHEK2 mutations and colorectal cancer risk: different effects of a missense and truncating mutations?Semantic proximity Read ↗

CHEK2 I157T associates with familial and sporadic colorectal cancerSemantic proximity Read ↗

Effect of CHEK2 missense variant I157T on the risk of breast cancer in carriers of other CHEK2 or BRCA1 mutations.Semantic proximity Read ↗

Haplotypes of the I157T CHEK2 germline mutation in ethnically diverse populations.Semantic proximity Read ↗

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Patient survival and tumor characteristics associated with CHEK2:p.I157T – findings from the Breast Cancer Association ConsortiumSemantic proximity Read ↗

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