Article
CHEK2 variant I157T may be associated with increased breast cancer risk.
International journal of cancer - 10 Sept 2004
Kilpivaara Outi, Vahteristo Pia, Falck Jacob, Syrjäkoski Kirsi, Eerola Hannaleena, Easton Douglas, Bartkova Jirina, Lukas Jiri, Heikkilä Päivi, Aittomäki Kristiina, Holli Kaija, Blomqvist Carl, Kallioniemi Olli-Pekka, Bartek Jiri, Nevanlinna Heli
Abstract excerpt
Cell cycle checkpoint kinase 2 (CHEK2) is a transducer of cellular responses to DNA damage. The CHEK2 1100delC has previously been shown to be a low-penetrance breast cancer susceptibility allele. We have evaluated the role of another CHEK2 variant, I157T in the FHA domain of the gene, for association with breast cancer. I157T was found at a significantly higher frequency in the population-based series of breast...
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