Article
Variants in CHEK2 other than 1100delC do not make a major contribution to breast cancer susceptibility.
American journal of human genetics - 1 Apr 2003
Schutte Mieke, Seal Sheila, Barfoot Rita, Meijers-Heijboer Hanne, Wasielewski Marijke, Evans D Gareth, Eccles Diana, Meijers Carel, Lohman Frans, Klijn Jan, van den Ouweland Ans, Futreal P Andrew, Nathanson Katherine L, Weber Barbara L, Easton Douglas F, Stratton Michael R, Rahman Nazneen
Abstract excerpt
We recently reported that a sequence variant in the cell-cycle-checkpoint kinase CHEK2 (CHEK2 1100delC) is a low-penetrance breast cancer-susceptibility allele in noncarriers of BRCA1 or BRCA2 mutations. To investigate whether other CHEK2 variants confer susceptibility to breast cancer, we screened the full CHEK2 coding sequence in BRCA1/2-negative breast cancer cases from 89 pedigrees with three or more cases of...
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