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Article

Nuclear Factor I-C acts as a regulator of hepatocyte proliferation at the onset of liver regeneration.

Liver international : official journal of the International Association for the Study of the Liver - 1 Apr 2015

Edelmann Simone, Fahrner René, Malinka Thomas, Song Bryan H, Stroka Deborah, Mermod Nicolas

Abstract excerpt

BACKGROUND & AIMS: Knockout studies of the murine Nuclear Factor I-C (NFI-C) transcription factor revealed abnormal skin wound healing and growth of its appendages, suggesting a role in controlling cell proliferation in adult regenerative processes. Liver regeneration following partial hepatectomy (PH) is a well-established regenerative model whereby changes elicited in hepatocytes lead to their rapid and phased...

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Source

Identifiers

PMID: 25293436
DOI: 10.1111/liv.12697

Genes

HGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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