Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

FANCJ/BACH1 acetylation at lysine 1249 regulates the DNA damage response.

PLoS genetics - 1 Jul 2012

Xie Jenny, Peng Min, Guillemette Shawna, Quan Steven, Maniatis Stephanie, Wu Yuliang, Venkatesh Aditya, Shaffer Scott A, Brosh Robert M, Cantor Sharon B

Abstract excerpt

BRCA1 promotes DNA repair through interactions with multiple proteins, including CtIP and FANCJ (also known as BRIP1/BACH1). While CtIP facilitates DNA end resection when de-acetylated, the function of FANCJ in repair processing is less well defined. Here, we report that FANCJ is also acetylated....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to Basic-Leucine Zipper Transcription Factors
Share to BRCA1 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fanconi Anemia Complementation Group Proteins

Share to G2 Phase Cell Cycle Checkpoints

Share to Histone Acetyltransferases

Share to Homologous Recombination

Share to Lysine

Source

Open in PubMed Open full text

Identifiers

PMID: 22792074
DOI: 10.1371/journal.pgen.1002786
PMCID: PMC3390368

Genes

BACH1
BRCA1
BRIP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22792074-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FANCJ/BACH1 acetylation at lysine 1249 regulates the DNA damage response.PMID 22792074Read ↗

The Interaction of CtIP and Nbs1 Connects CDK and ATM to Regulate HR–Mediated Double-Strand Break RepairSemantic proximity Read ↗

PCAF-Mediated Histone Acetylation Promotes Replication Fork Degradation by MRE11 and EXO1 in BRCA-Deficient Cells.Semantic proximity Read ↗

The TIP60-ATM axis regulates replication fork stability in BRCA-deficient cellsSemantic proximity Read ↗

The FANCM-RMI1/2 complex promotes genomic instability and PARP inhibitor sensitivity in BRCA2-deficicient cellsSemantic proximity Read ↗

RAD51C facilitates checkpoint signaling by promoting CHK2 phosphorylationSemantic proximity Read ↗

H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJSemantic proximity Read ↗

CSB interacts with BRCA1 in late S/G2 to promote MRN- and CtIP-mediated DNA end resectionSemantic proximity Read ↗

The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediatorSemantic proximity Read ↗

CtIP-dependent DNA resection is required for DNA damage checkpoint maintenance but not initiationSemantic proximity Read ↗

Controlling DNA-end resection: a new task for CDKsSemantic proximity Read ↗

ASF1a Promotes Non-homologous End Joining Repair by Facilitating Phosphorylation of MDC1 by ATM at Double-Strand BreaksSemantic proximity Read ↗

Assessing the link between BACH1/FANCJ and MLH1 in DNA crosslink repair.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.