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Article

Assessing the link between BACH1/FANCJ and MLH1 in DNA crosslink repair.

Environmental and molecular mutagenesis - 1 Jul 2010

Cantor Sharon B, Xie Jenny

Abstract excerpt

FANCJ (also known as BRIP1 or BACH1) is a DNA helicase that was originally identified by its direct interaction with the hereditary breast cancer protein, BRCA1. Similar to BRCA1, FANCJ function is essential for DNA repair and breast cancer suppression. FANCJ is also mutated in the cancer prone syndrome Fanconi anemia, for which patient cells are characterized by extreme sensitivity to agents that generate DNA...

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Topics

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20658644
DOI: 10.1002/em.20568

Genes

MLH1
BRCA1
BACH1
BRIP1

Provenance

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Assessing the link between BACH1/FANCJ and MLH1 in DNA crosslink repair.PMID 20658644Read ↗

The DNA helicase FANCJ (BRIP1) functions in Double Strand Break repair processing, but not crossover formation during Prophase I of meiosis in male miceSemantic proximity Read ↗

Hereditary breast cancer and the BRCA1-associated FANCJ/BACH1/BRIP1.Semantic proximity Read ↗

BRCA1-mediated repression of mutagenic end-joining of DNA double-strand breaks requires complex formation with BACH1.Semantic proximity Read ↗

Functional and physical interaction between the mismatch repair and FA-BRCA pathwaysSemantic proximity Read ↗

An MLH1 mutation links BACH1/FANCJ to colon cancer, signaling, and insight toward directed therapy.Semantic proximity Read ↗

The DNA helicase FANCJ (BRIP1) functions in double strand break repair processing, but not crossover formation during prophase I of meiosis in male mice.Semantic proximity Read ↗

Crosslinks and crosstalk: human cancer syndromes and DNA repair defects.Semantic proximity Read ↗

Expanded roles of the Fanconi anemia pathway in preserving genomic stability.Semantic proximity Read ↗

Cellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: mechanistic insights.Semantic proximity Read ↗

Defects in homologous recombination repair behind the human diseases: FA and HBOCSemantic proximity Read ↗

Rad5-dependent DNA repair functions of the Saccharomyces cerevisiae FANCM protein homolog Mph1.Semantic proximity Read ↗

Interplay between Fanconi anemia and homologous recombination pathways in genome integrity.Semantic proximity Read ↗

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