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Article

Association of COMT gene polymorphisms with systemic atherosclerosis in elderly Japanese.

Journal of atherosclerosis and thrombosis - 1 Jan 2012

Ko Maung Kyi Chan, Ikeda Shinobu, Mieno-Naka Makiko, Arai Tomio, Zaidi Syed Ali Hyder, Sato Noriko, Muramatsu Masaaki, Sawabe Motoji

Abstract excerpt

AIM: Atherosclerotic disease is a major health problem among the elderly, which arises from a complex interaction between genetic and environmental factors. The catechol-O-methyltransferase (COMT) gene encodes an enzyme that degrades catecholamines and estrogens to less active metabolites. The objective of this study was to examine whether polymorphisms of the COMT gene affected the severity of atherosclerotic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22790479
DOI: 10.5551/jat.11254

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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