Association between Val158Met functional polymorphism in the COMT gene and risk of preeclampsia in a Chinese population.

doi:10.1016/j.arcmed.2012.03.002

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Article

Association between Val158Met functional polymorphism in the COMT gene and risk of preeclampsia in a Chinese population.

Archives of medical research - 1 Feb 2012

Liang Shanshan, Liu Xinghui, Fan Ping, Liu Rui, Zhang Juan, He Guolin, Liu Yu, Bai Huai

Abstract excerpt

BACKGROUND AND AIMS: The catechol-O-methyltransferase (COMT) gene is a potential candidate in altering risk for preeclampsia due to the important enzymatic effects in the metabolism of steroid hormones. It contains a non-synonymous G-A base change at codon 158 in the membrane bound isoform, which leads to a valine-to-methionine amino acid substitution. In the soluble isoform the polymorphism rs4680 is located in...

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PMID: 22475780
DOI: 10.1016/j.arcmed.2012.03.002

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COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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Association between Val158Met functional polymorphism in the COMT gene and risk of preeclampsia in a Chinese population.PMID 22475780Read ↗

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