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Article

Amelioration of intrathymic T cell development and peripheral T cell reactivities in autoimmune mice undergoing therapy with a novel immunomodulator.

International immunology - 1 Jan 1990

Spetz-Hagberg A L, Goldschmidt T J, Stålhandske T, Larsson-Sciard E L

Abstract excerpt

MRL lpr/lpr mice develop a generalized autoimmune disease associated with a massive accumulation in the peripheral lymphoid organs of abnormal, phenotypically immature T cells. Both the lymphoadenopathy and the autoimmunity are thymus-dependent and likely to arise from an aberrant pathway of intrathymic differentiation. We here present the marked beneficial effects acquired in MRL lpr/lpr mice after in vivo...

Topics

Adjuvants, Immunologic
Animals
Autoimmune Diseases
Cell Count
Cell Differentiation
Hydroxyquinolines
Lymphocyte Activation
Mice
Mice, Mutant Strains
Phenotype
T-Lymphocyte Subsets

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T-Lymphocytes

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Identifiers

PMID: 2278995
DOI: 10.1093/intimm/2.7.645

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2278995-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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