Article
Repeated alpha-galactosylceramide administration results in expansion of NK T cells and alleviates inflammatory dermatitis in MRL-lpr/lpr mice.
Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 2003
Yang Jun-Qi, Saxena Vijay, Xu Honglin, Van Kaer Luc, Wang Chyung-Ru, Singh Ram Raj
Abstract excerpt
NK T (NKT) cells expressing the invariant Valpha14-Jalpha18 TCR alpha-chain recognize glycolipid Ags such as alpha-galactosylceramide (alpha-GalCer) presented by the MHC class I-like molecule CD1d. Upon activation by alpha-GalCer, invariant NKT cells secrete multiple cytokines and confer protection in certain immune-mediated disorders. Here we have investigated the role of NKT cells in the development of...
Topics
- Animals
- Cell Division
- Dermatitis
- Drug Administration Schedule
- Female
- Galactosylceramides
- Genetic Predisposition to Disease
- Injections, Intraperitoneal
- Killer Cells, Natural
- Lupus Nephritis
- Lymphocyte Activation
- Lymphocyte Count
- Lymphopenia