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Article

Repeated alpha-galactosylceramide administration results in expansion of NK T cells and alleviates inflammatory dermatitis in MRL-lpr/lpr mice.

Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 2003

Yang Jun-Qi, Saxena Vijay, Xu Honglin, Van Kaer Luc, Wang Chyung-Ru, Singh Ram Raj

Abstract excerpt

NK T (NKT) cells expressing the invariant Valpha14-Jalpha18 TCR alpha-chain recognize glycolipid Ags such as alpha-galactosylceramide (alpha-GalCer) presented by the MHC class I-like molecule CD1d. Upon activation by alpha-GalCer, invariant NKT cells secrete multiple cytokines and confer protection in certain immune-mediated disorders. Here we have investigated the role of NKT cells in the development of...

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Identifiers

PMID: 14530371
DOI: 10.4049/jimmunol.171.8.4439

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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