Calorie restriction modulates lymphocyte subset phenotype and increases apoptosis in MRL/lpr mice.

doi:10.1016/0165-2478(95)00091-5

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Article

Calorie restriction modulates lymphocyte subset phenotype and increases apoptosis in MRL/lpr mice.

Immunology letters - 1 Sept 1995

Luan X, Zhao W, Chandrasekar B, Fernandes G

Abstract excerpt

Defective expression of the Fas apoptotic gene may account for overproduction of CD4- CD8- B220+ cells (double-negative) in MRL/MpJ-lpr/lpr (lpr) mice. Previous studies have shown that calorie restriction (CR) inhibits the development of autoimmune disease and extends life span in these animals....

Topics

Animals
Antibodies, Antinuclear
Apoptosis
Autoimmune Diseases
Body Weight
CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
Cytokines
Dexamethasone
Energy Intake
Female
Flow Cytometry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymph Nodes

Lymphocyte Activation

Mice

Mice, Mutant Strains

Organ Size

Phenotype

Source

Open in PubMed

Identifiers

PMID: 8747716
DOI: 10.1016/0165-2478(95)00091-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8747716-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Calorie restriction modulates lymphocyte subset phenotype and increases apoptosis in MRL/lpr mice.PMID 8747716Read ↗

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Dietary restriction and fasting arrest B and T cell development and increase mature B and T cell numbers in bone marrow.Semantic proximity Read ↗

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