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Article

Calorie restriction modulates lymphocyte subset phenotype and increases apoptosis in MRL/lpr mice.

Immunology letters - 1 Sept 1995

Luan X, Zhao W, Chandrasekar B, Fernandes G

Abstract excerpt

Defective expression of the Fas apoptotic gene may account for overproduction of CD4- CD8- B220+ cells (double-negative) in MRL/MpJ-lpr/lpr (lpr) mice. Previous studies have shown that calorie restriction (CR) inhibits the development of autoimmune disease and extends life span in these animals. The present studies describe the effects of CR on the distribution of lymphocyte phenotypes, lymphocyte proliferative...

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Identifiers

PMID: 8747716
DOI: 10.1016/0165-2478(95)00091-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Calorie restriction modulates lymphocyte subset phenotype and increases apoptosis in MRL/lpr mice.PMID 8747716Read ↗

Overexpression of Mcl-1 exacerbates lymphocyte accumulation and autoimmune kidney disease in lpr mice.Semantic proximity Read ↗

Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci.Semantic proximity Read ↗

Calorie-related rapid onset of alveolar loss, regeneration, and changes in mouse lung gene expressionSemantic proximity Read ↗

FcRγ promotes T cell apoptosis in Fas-deficient mice.Semantic proximity Read ↗

Hypo-active variant of IL-2 and associated decreased T cell activation contribute to impaired apoptosis in autoimmune prone MRL mice.Semantic proximity Read ↗

Dietary restriction and fasting arrest B and T cell development and increase mature B and T cell numbers in bone marrow.Semantic proximity Read ↗

FcγRIIB Deficiency Leads to Autoimmunity and a Defective Response to Apoptosis in Mrl-MpJ MiceSemantic proximity Read ↗

The APO-1/Fas (CD95) receptor is expressed in homozygous MRL/lpr mice.Semantic proximity Read ↗

Expression of a Pim-1 transgene accelerates lymphoproliferation and inhibits apoptosis in lpr/lpr mice.Semantic proximity Read ↗

Naive CD4+ T cells from lupus-prone Fas-intact MRL mice display TCR-mediated hyperproliferation due to intrinsic threshold defects in activation.Semantic proximity Read ↗

A single injection of Staphylococcus aureus enterotoxin B reduces autoimmunity in MRL/lpr mice.Semantic proximity Read ↗

Treadmill exercise in mice increases intestinal lymphocyte loss via apoptosis.Semantic proximity Read ↗

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