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Article

Association of polymorphism of PTPN 11 encoding SHP-2 with gastric atrophy but not gastric cancer in Helicobacter pylori seropositive Chinese population.

BMC gastroenterology - 12 Jul 2012

Jiang Jing, Jia Zhi-Fang, Kong Fei, Jin Mei-Shan, Wang Yin-Ping, Tian Suyan, Suo Jian, Cao Xueyuan

Abstract excerpt

BACKGROUND: The interaction between Src homology 2 domain-containing protein tyrosine phosphatase (SHP-2) of gastric epithelial cells and cagA from H. pylori plays a crucial role in developments of gastric atrophy and gastric cancer. This study aimed to investigate the association of haplotype tagging SNPs (htSNPs) in the PTPN11 gene encoding SHP-2 with gastric atrophy and gastric cancer in Chinese population....

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Source

Open in PubMed Open full text

Identifiers

PMID: 22788847
DOI: 10.1186/1471-230X-12-89
PMCID: PMC3509400

Genes

PTPN11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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