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Article

Significant association between PTPN11 polymorphism and gastric atrophy among Japanese Brazilians.

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association - 1 Jan 2006

Kawai Sayo, Goto Yasuyuki, Ito Lucy S, Oba-Shinjo Sueli M, Uno Miyuki, Shinjo Samuel K, Marie Suely K N, Ishida Yoshiko, Nishio Kazuko, Naito Mariko, Hamajima Nobuyuki

Abstract excerpt

BACKGROUND: Helicobacter pylori, especially the cytotoxin-associated antigen A (cagA)-positive strains, plays a crucial role in the development of gastric atrophy and gastric cancer. CagA delivered into gastric epithelial cells combines with src homology 2 domain-containing protein tyrosine phosphatase-2 (SHP-2), possibly leading to atrophy/cancer. Our previous study found that a single-nucleotide polymorphism...

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Source

Identifiers

PMID: 17235629
DOI: 10.1007/s10120-006-0391-6

Genes

PTPN11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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