Article
Colon cancer associated genes exhibit signatures of positive selection at functionally significant positions.
BMC evolutionary biology - 12 Jul 2012
Morgan Claire C, Shakya Kabita, Webb Andrew, Walsh Thomas A, Lynch Mark, Loscher Christine E, Ruskin Heather J, O'Connell Mary J
Abstract excerpt
BACKGROUND: Cancer, much like most human disease, is routinely studied by utilizing model organisms. Of these model organisms, mice are often dominant. However, our assumptions of functional equivalence fail to consider the opportunity for divergence conferred by ~180 Million Years (MY) of independent evolution between these species. For a given set of human disease related genes, it is therefore important to...
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