Article
The role of positive selection in determining the molecular cause of species differences in disease.
BMC evolutionary biology - 6 Oct 2008
Vamathevan Jessica J, Hasan Samiul, Emes Richard D, Amrine-Madsen Heather, Rajagopalan Dilip, Topp Simon D, Kumar Vinod, Word Michael, Simmons Mark D, Foord Steven M, Sanseau Philippe, Yang Ziheng, Holbrook Joanna D
Abstract excerpt
BACKGROUND: Related species, such as humans and chimpanzees, often experience the same disease with varying degrees of pathology, as seen in the cases of Alzheimer's disease, or differing symptomatology as in AIDS. Furthermore, certain diseases such as schizophrenia, epithelial cancers and autoimmune disorders are far more frequent in humans than in other species for reasons not associated with lifestyle. Genes...
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