Article
Large-scale replication and heterogeneity in Parkinson disease genetic loci.
Neurology - 14 Aug 2012
Sharma Manu, Ioannidis John P A, Aasly Jan O, Annesi Grazia, Brice Alexis, Van Broeckhoven Christine, Bertram Lars, Bozi Maria, Crosiers David, Clarke Carl, Facheris Maurizio, Farrer Matthew, Garraux Gaetan, Gispert Suzana, Auburger Georg, Vilariño-Güell Carles, Hadjigeorgiou Georgios M, Hicks Andrew A, Hattori Nobutaka, Jeon Beom, Lesage Suzanne, Lill Christina M, Lin Juei-Jueng, Lynch Timothy, Lichtner Peter, Lang Anthony E, Mok Vincent, Jasinska-Myga Barbara, Mellick George D, Morrison Karen E, Opala Grzegorz, Pramstaller Peter P, Pichler Irene, Park Sung Sup, Quattrone Aldo, Rogaeva Ekaterina, Ross Owen A, Stefanis Leonidas, Stockton Joanne D, Satake Wataru, Silburn Peter A, Theuns Jessie, Tan Eng-King, Toda Tatsushi, Tomiyama Hiroyuki, Uitti Ryan J, Wirdefeldt Karin, Wszolek Zbigniew, Xiromerisiou Georgia, Yueh Kuo-Chu, Zhao Yi, Gasser Thomas, Maraganore Demetrius, Krüger Rejko
Abstract excerpt
OBJECTIVE: Eleven genetic loci have reached genome-wide significance in a recent meta-analysis of genome-wide association studies in Parkinson disease (PD) based on populations of Caucasian descent. The extent to which these genetic effects are consistent across different populations is unknown. METHODS: Investigators from the Genetic Epidemiology of Parkinson's Disease Consortium were invited to participate in...
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