Article
Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international study.
The Lancet. Neurology - 1 Nov 2006
Elbaz Alexis, Nelson Lorene M, Payami Haydeh, Ioannidis John P A, Fiske Brian K, Annesi Grazia, Carmine Belin Andrea, Factor Stewart A, Ferrarese Carlo, Hadjigeorgiou Georgios M, Higgins Donald S, Kawakami Hideshi, Krüger Rejko, Marder Karen S, Mayeux Richard P, Mellick George D, Nutt John G, Ritz Beate, Samii Ali, Tanner Caroline M, Van Broeckhoven Christine, Van Den Eeden Stephen K, Wirdefeldt Karin, Zabetian Cyrus P, Dehem Marie, Montimurro Jennifer S, Southwick Audrey, Myers Richard M, Trikalinos Thomas A
Abstract excerpt
BACKGROUND: A genome-wide association study identified 13 single-nucleotide polymorphisms (SNPs) significantly associated with Parkinson's disease. Small-scale replication studies were largely non-confirmatory, but a meta-analysis that included data from the original study could not exclude all SNP associations, leaving relevance of several markers uncertain. METHODS: Investigators from three Michael J Fox...
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